Toxoplasmosis complications and novel therapeutic synergism combination of diclazuril plus atovaquone
نویسندگان
چکیده
منابع مشابه
Toxoplasmosis complications and novel therapeutic synergism combination of diclazuril plus atovaquone
UNLABELLED Toxoplasmosis is a major cause of foodborne disease, congenital complication, and morbidity. There is an urgent need for safe and effective therapies to encounter congenital and persisting toxoplasmosis. The hypothesis was: combination diclazuril plus atovaquone to exert a novel therapeutic synergy to prevent toxoplasmosis syndromes. METHODS Pregnant dams were treated with diclazur...
متن کاملNovel Synergistic Protective Efficacy of Atovaquone and Diclazuril on Fetal-Maternal Toxoplasmosis.
Over 1 billion people globally are estimated to be infected with Toxoplasma gondii with severe or unknown consequences and no safe and effective therapies are available against congenital or persistent chronic infection. We propose that atovaquone and diclazuril synergistically protect against fetal-maternal toxoplasmosis. METHODS Programmed pregnant mice were treated with atovaquone and dicl...
متن کاملAtovaquone ameliorate gastrointestinal Toxoplasmosis complications in a pregnancy model
BACKGROUND Toxoplasma is an important source of foodborne hospitalization with no safe and effective therapy against chronic or congenital Toxopalsmosis. Atovaquone is a drug of choice but not approved for use in congenital Toxoplasmosis. We hypothesized atovaquone to be safe and effective against feto-maternal Toxoplasmosis. MATERIAL/METHODS Programmed pregnant mice were i.p. infected with 5...
متن کاملDiclazuril Protects against Maternal Gastrointestinal Syndrome and Congenital Toxoplasmosis
BACKGROUND Toxoplasmosis is a common cause of foodborne, gastrointestinal and congenital syndrome with particularly severe or unknown health consequences. There is no safe and effective preventive or therapeutic modality against congenital toxoplasmosis or to eliminate the persistent chronic infection. HYPOTHESIS Diclazuril to be safe in pregnancy and effective against gastrointestinal toxopl...
متن کاملAtovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis.
Immunocompromised patients are at risk of developing toxoplasma encephalitis (TE). Standard therapy regimens (including sulfadiazine plus pyrimethamine) are hampered by severe side effects. While atovaquone has potent in vitro activity against Toxoplasma gondii, it is poorly absorbed after oral administration and shows poor therapeutic efficacy against TE. To overcome the low absorption of atov...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2014
ISSN: 1664-302X
DOI: 10.3389/fmicb.2014.00484